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Nonlinear Relation Between Burst Dorsal Root Ganglion Stimulation Amplitude and Behavioral Outcome in an Experimental Model of Painful Diabetic Peripheral Neuropathy.
Franken, Glenn; Debets, Jacques; Joosten, Elbert A J.
Affiliation
  • Franken G; Pain Management and Research Centre, Department of Anesthesiology and Pain Management, MUMC, Maastricht, The Netherlands.
  • Debets J; School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Joosten EAJ; Muroidean Facility, School of Cardiovascular Diseases, CARIM, Maastricht, The Netherlands.
Neuromodulation ; 23(2): 158-166, 2020 Feb.
Article de En | MEDLINE | ID: mdl-31738474
BACKGROUND AND OBJECTIVE: Dorsal root ganglion stimulation (DRGS) has recently emerged as a neuromodulation modality in the treatment of chronic neuropathic pain. The objective of this study was to compare the efficacy of different Burst-DRGS amplitudes in an experimental model of painful diabetic peripheral neuropathy (PDPN). METHODS: Diabetes mellitus was induced in female Sprague-Dawley rats by intraperitoneal injection of streptozotocin (STZ, n = 28). Animals were tested for mechanical hypersensitivity (von Frey paw withdrawal test) before, and four weeks after STZ injection. PDPN rats (n = 13) were implanted with a unilateral bipolar electrode at the L5 DRG. Animals received Burst-DRGS at 0%, 10%, 33%, 50%, 66%, and 80% of motor threshold (MT) in a randomized crossover design on post-implantation days 2-7 (n = 9). Mechanical hypersensitivity was assessed before stimulation onset, 15 and 30 min during stimulation, and 15 and 30 min after stimulation. RESULTS: Burst-DRGS at amplitudes of 33%, 50%, 66%, and 80% MT resulted in significant attenuation of STZ-induced mechanical hypersensitivity at 15 and 30 min during stimulation, as well as 15 min after cessation of stimulation. No effect on mechanical hypersensitivity was observed for Burst-DRGS at 0% MT and 10% MT. Optimal pain relief and highest responder rates were achieved with Burst-DRGS at 50-66% MT, with an estimated optimum at 52% MT. CONCLUSION: Our findings indicate a nonlinear relationship between Burst-DRGS amplitude and behavioral outcome, with an estimated optimal amplitude of 52% MT. Further optimization and analysis of DRGS driven by insights into the underlying mechanisms related to the various stimulation paradigms is warranted.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Dynamique non linéaire / Diabète expérimental / Neuropathies diabétiques / Gestion de la douleur / Stimulation de la moelle épinière / Ganglions sensitifs des nerfs spinaux Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: Neuromodulation Année: 2020 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Dynamique non linéaire / Diabète expérimental / Neuropathies diabétiques / Gestion de la douleur / Stimulation de la moelle épinière / Ganglions sensitifs des nerfs spinaux Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: Neuromodulation Année: 2020 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: États-Unis d'Amérique