A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Dawson, John C; Serrels, Bryan; Byron, Adam; Muir, Morwenna T; Makda, Ashraff; García-Muñoz, Amaya; von Kriegsheim, Alex; Lietha, Daniel; Carragher, Neil O; Frame, Margaret C

Dawson, John C; Serrels, Bryan; Byron, Adam; Muir, Morwenna T; Makda, Ashraff; García-Muñoz, Amaya; von Kriegsheim, Alex; Lietha, Daniel; Carragher, Neil O; Frame, Margaret C.

Affiliation

Dawson JC; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Serrels B; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Byron A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Muir MT; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Makda A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
García-Muñoz A; Systems Biology Ireland, University College Dublin, Dublin, Ireland.
von Kriegsheim A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Lietha D; Systems Biology Ireland, University College Dublin, Dublin, Ireland.
Carragher NO; Cell Signaling and Adhesion Group, Structural Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Frame MC; Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. m.frame@ed.ac.uk n.carragher@ed.ac.uk.

Mol Cancer Ther ; 19(2): 637-649, 2020 02.

Article de En | MEDLINE | ID: mdl-31784455

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Focal adhesion protein-tyrosine kinases / Inhibiteurs de désacétylase d'histone / Tumeurs Limites: Animals / Humans Langue: En Journal: Mol Cancer Ther Sujet du journal: ANTINEOPLASICOS Année: 2020 Type de document: Article Pays d'affiliation: Royaume-Uni

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