Excretion of 4-fluoroamphetamine and three metabolites in urine after controlled oral ingestion.
J Pharm Biomed Anal
; 179: 113008, 2020 Feb 05.
Article
de En
| MEDLINE
| ID: mdl-31785931
ABSTRACT
Each year, synthetic drugs are occurring in high numbers in the illicit drug market. But data on their pharmacology and toxicology are scarcely available. Therefore, a pilot study was performed to evaluate excretion of 4-fluoroamphetamine (4FA) in humans and identify metabolites in urine. Twelve subjects ingested 100â¯mg and five 150â¯mg 4-FA in a bitter lemon drink. Urine samples were scheduled at baseline and 4 times during the following 12â¯h and analyzed by liquid chromatography-mass spectrometry (LC-MSMS). Concentrations of 4-FA were in the range of 0.7-38â¯mg/l which is in accordance with the data in previously reported cases. A marked decrease of creatinine excretion in the first two samples was noted. The creatinine normalized concentrations show a maximum 4â¯h after ingestion in accordance with serum pharmacokinetics. Three products of two metabolic pathways were identified in very low concentrations, two diastereomers of 4-fluorophenylpropanolamine and one ring hydroxylated 4-FA that was conjugated to a large extent. The concentration-time courses paralleled those of 4-FA. The study results show the range of 4-FA concentrations to be expected in urine after oral ingestion of typical dosages and show two pathways of 4-FA metabolism.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Chromatographie en phase liquide
/
Spectrométrie de masse en tandem
/
Amphétamines
Type d'étude:
Clinical_trials
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Pharm Biomed Anal
Année:
2020
Type de document:
Article