Optical Control of Cytokine Production Using Photoswitchable Galactosylceramides.
Chemistry
; 26(20): 4476-4479, 2020 Apr 06.
Article
de En
| MEDLINE
| ID: mdl-31788876
ABSTRACT
α-Galactosylceramides are glycosphingolipids that show promise in cancer immunotherapy. After presentation by CD1d, they activate natural killer T cells (NKT), which results in the production of a variety of pro-inflammatory and immunomodulatory cytokines. Herein, we report the synthesis and biological evaluation of photochromic derivatives of KRN-7000, the activity of which can be modulated with light. Based on established structure-activity relationships, we designed photoswitchable analogues of this glycolipid that control the production of pro-inflammatory cytokines, such as IFN-γ. The azobenzene derivative α-GalACer-4 proved to be more potent than KRN-7000 itself when activated with 370â
nm light. Photolipids of this type could improve our mechanistic understanding of cytokine production and could open new directions in photoimmunotherapy.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Glycolipides
/
Cellules tueuses naturelles
/
Cytokines
/
Antigène CD1d
/
Galactosylcéramides
Langue:
En
Journal:
Chemistry
Sujet du journal:
QUIMICA
Année:
2020
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique