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Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes.
Kim, Ki Wook; Allen, Digby W; Briese, Thomas; Couper, Jennifer J; Barry, Simon C; Colman, Peter G; Cotterill, Andrew M; Davis, Elizabeth A; Giles, Lynne C; Harrison, Leonard C; Harris, Mark; Haynes, Aveni; Horton, Jessica L; Isaacs, Sonia R; Jain, Komal; Lipkin, Walter I; McGorm, Kelly; Morahan, Grant; Morbey, Claire; Pang, Ignatius C N; Papenfuss, Anthony T; Penno, Megan A S; Sinnott, Richard O; Soldatos, Georgia; Thomson, Rebecca L; Vuillermin, Peter; Wentworth, John M; Wilkins, Marc R; Rawlinson, William D; Craig, Maria E.
Affiliation
  • Kim KW; School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
  • Allen DW; School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
  • Briese T; Center for Infection and Immunity and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
  • Couper JJ; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Barry SC; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Colman PG; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital Victoria, Melbourne, Victoria, Australia.
  • Cotterill AM; Department of Endocrinology, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
  • Davis EA; Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
  • Giles LC; School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
  • Harrison LC; Walter and Eliza Hall Institute and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  • Harris M; Department of Endocrinology, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
  • Haynes A; Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
  • Horton JL; School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
  • Isaacs SR; School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
  • Jain K; Center for Infection and Immunity and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
  • Lipkin WI; Center for Infection and Immunity and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
  • McGorm K; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Morahan G; Centre for Diabetes Research, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia.
  • Morbey C; Hunter Diabetes Centre, Newcastle, New South Wales, Australia.
  • Pang ICN; School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, New South Wales, Australia.
  • Papenfuss AT; Walter and Eliza Hall Institute and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  • Penno MAS; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Sinnott RO; Department of Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia.
  • Soldatos G; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
  • Thomson RL; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Vuillermin P; School of Medicine, Deakin University, Geelong, Victoria, Australia.
  • Wentworth JM; Walter and Eliza Hall Institute and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  • Wilkins MR; School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, New South Wales, Australia.
  • Rawlinson WD; School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
  • Craig ME; Serology and Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Pediatr Diabetes ; 21(2): 271-279, 2020 03.
Article de En | MEDLINE | ID: mdl-31800147
ABSTRACT

BACKGROUND:

Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compared to the bacterial microbiome, very little is known about the virome. We set out to characterize longitudinal changes in the gut virome of healthy infants born to mothers with or without type 1 diabetes using comprehensive virome capture sequencing.

METHODS:

Healthy infants were selected from Environmental Determinants of Islet Autoimmunity (ENDIA), a prospective cohort of Australian children with a first-degree relative with type 1 diabetes, followed from pregnancy. Fecal specimens were collected three-monthly in the first year of life.

RESULTS:

Among 25 infants (44% born to mothers with type 1 diabetes) at least one virus was detected in 65% (65/100) of samples and 96% (24/25) of infants during the first year of life. In total, 26 genera of viruses were identified and >150 viruses were differentially abundant between the gut of infants with a mother with type 1 diabetes vs without. Positivity for any virus was associated with maternal type 1 diabetes and older infant age. Enterovirus was associated with older infant age and maternal smoking.

CONCLUSIONS:

We demonstrate a distinct gut virome profile in infants of mothers with type 1 diabetes, which may influence health outcomes later in life. Higher prevalence and greater number of viruses observed compared to previous studies suggests significant underrepresentation in existing virome datasets, arising most likely from less sensitive techniques used in data acquisition.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Grossesse chez les diabétiques / Nouveau-né / Diabète de type 1 / Microbiome gastro-intestinal / Virome Type d'étude: Observational_studies / Risk_factors_studies Limites: Female / Humans / Male / Pregnancy Langue: En Journal: Pediatr Diabetes Sujet du journal: ENDOCRINOLOGIA Année: 2020 Type de document: Article Pays d'affiliation: Australie
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Grossesse chez les diabétiques / Nouveau-né / Diabète de type 1 / Microbiome gastro-intestinal / Virome Type d'étude: Observational_studies / Risk_factors_studies Limites: Female / Humans / Male / Pregnancy Langue: En Journal: Pediatr Diabetes Sujet du journal: ENDOCRINOLOGIA Année: 2020 Type de document: Article Pays d'affiliation: Australie