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Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.
Guo, Junsong; Chen, Bingyi; Yu, Ying; Cheng, Bao; Cheng, Yanfang; Ju, Yingchen; Gu, Qiong; Xu, Jun; Zhou, Huihao.
Affiliation
  • Guo J; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Chen B; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Yu Y; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Cheng B; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Cheng Y; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Ju Y; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Gu Q; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Xu J; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Zhou H; Research Center for Drug Discovery, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: zhuihao@mail.sysu.edu.cn.
Eur J Med Chem ; 187: 111941, 2020 Feb 01.
Article de En | MEDLINE | ID: mdl-31821989
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Threonine-tRNA ligase / ARN de transfert spécifiques des différents acides aminés / Découverte de médicament Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2020 Type de document: Article Pays d'affiliation: Chine Pays de publication: France
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Threonine-tRNA ligase / ARN de transfert spécifiques des différents acides aminés / Découverte de médicament Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2020 Type de document: Article Pays d'affiliation: Chine Pays de publication: France