Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function.
Mol Neurobiol
; 57(3): 1716-1732, 2020 Mar.
Article
de En
| MEDLINE
| ID: mdl-31823198
ABSTRACT
The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a type of post-translational modification which is important for numerous cellular processes, including mRNA splicing, DNA repair, signal transduction, protein interaction, and transport. PRMTs have been extensively associated with various pathologies, including cancer, inflammation, and immunity response. However, the role of PRMTs has not been well described in vascular and neurological function. Aberrant expression of PRMTs can alter its metabolic products, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA). Increased ADMA levels are recognized as an independent risk factor for cardiovascular disease and mortality. Recent studies have provided considerable advances in the development of small-molecule inhibitors of PRMTs to study their function under normal and pathological states. In this review, we aim to elucidate the particular roles of PRMTs in vascular and neuronal function as a potential target for cardiovascular and neurological diseases.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arginine
/
Protein-arginine N-methyltransferases
/
Maladies cardiovasculaires
/
Système cardiovasculaire
Type d'étude:
Risk_factors_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Mol Neurobiol
Sujet du journal:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
Année:
2020
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique