Liver fibrosis and CD206<sup>+</sup> macrophage accumulation are suppressed by anti-GM-CSF therapy.

Tan-Garcia, Alfonso; Lai, Fritz; Sheng Yeong, Joe Poh; Irac, Sergio E; Ng, Pei Y; Msallam, Rasha; Tatt Lim, Jeffrey Chun; Wai, Lu-En; Tham, Christine Y L; Choo, Su P; Lim, Tony; Young, Dan Y; D'Ambrosio, Roberta; Degasperi, Elisabetta; Perbellini, Riccardo; Newell, Evan; Le Bert, Nina; Ginhoux, Florent; Bertoletti, Antonio; Chen, Qingfeng; Dutertre, Charles-Antoine

Liver fibrosis and CD206⁺ macrophage accumulation are suppressed by anti-GM-CSF therapy.

Tan-Garcia, Alfonso; Lai, Fritz; Sheng Yeong, Joe Poh; Irac, Sergio E; Ng, Pei Y; Msallam, Rasha; Tatt Lim, Jeffrey Chun; Wai, Lu-En; Tham, Christine Y L; Choo, Su P; Lim, Tony; Young, Dan Y; D'Ambrosio, Roberta; Degasperi, Elisabetta; Perbellini, Riccardo; Newell, Evan; Le Bert, Nina; Ginhoux, Florent; Bertoletti, Antonio; Chen, Qingfeng; Dutertre, Charles-Antoine.

Affiliation

Tan-Garcia A; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Lai F; Humanised Mouse Unit, Institute of Molecular and Cell Biology, ASTAR, 61 Biopolis Drive, Singapore 138673, Singapore.
Sheng Yeong JP; Department of Anatomical Pathology, Singapore General Hospital, Singapore.
Irac SE; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Ng PY; Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.
Msallam R; Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.
Tatt Lim JC; Department of Anatomical Pathology, Singapore General Hospital, Singapore.
Wai LE; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Tham CYL; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Choo SP; Department of Medical Oncology, National Cancer Centre, Singapore.
Lim T; Department of Anatomical Pathology, Singapore General Hospital, Singapore.
Young DY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore.
D'Ambrosio R; CRC "A.M. e A. Migliavacca" Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Degasperi E; CRC "A.M. e A. Migliavacca" Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Perbellini R; CRC "A.M. e A. Migliavacca" Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Newell E; Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.
Le Bert N; Fred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA, USA.
Ginhoux F; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Bertoletti A; Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.
Chen Q; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Dutertre CA; Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.

JHEP Rep ; 2(1): 100062, 2020 Feb.

Article de En | MEDLINE | ID: mdl-32039403

Mots clés

ALT, alanine aminotransferase; BAMBI, BMP and Activin Membrane-bound Inhibitor; CD206+ macrophages; DAA, direct-acting antiviral; DC, dendritic cell; FFPE, formalin-fixed paraffin-embedded; GM-CSF; GM-CSF, granulocyte-macrophage colony-stimulating factor; HCC, hepatocellular carcinoma; HCV; HIER, heat-induced epitope retrieval; HSC, hepatic stellate cells; ICS, intracellular cytokine staining; Intrahepatic macrophages; LPS, lipopolysaccharide; LSM, liver stiffness measurement; MS, multiple sclerosis; NASH; NASH, non-alcoholic steatohepatitis; PBMCs, peripheral blood mononuclear cells; RA, rheumatoid arthritis; SVR, sustained virological response; TCR, T cell receptor; TMA, tissue microarray; TNFα, tumour necrosis factor-α; TSA, tyramide signal amplification; anti-GM-CSF neutralizing antibody; fibrosis; moMΦs, monocyte-derived macrophage-like cells; t-SNE, t-distributed stochastic neighbour embedding

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: JHEP Rep Année: 2020 Type de document: Article Pays d'affiliation: Singapour Pays de publication: Pays-Bas

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