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Atypical immune response to Epstein-Barr virus in major depressive disorder.
Jones-Brando, Lorraine; Dickerson, Faith; Ford, Glen; Stallings, Cassie; Origoni, Andrea; Katsafanas, Emily; Sweeney, Kevin; Squire, Amalia; Khushalani, Sunil; Yolken, Robert.
Affiliation
  • Jones-Brando L; The Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, United States. Electronic address: lbrando@jhmi.edu.
  • Dickerson F; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Ford G; VanPelt Biosciences, Rockville, MD, United States.
  • Stallings C; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Origoni A; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Katsafanas E; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Sweeney K; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Squire A; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Khushalani S; The Stanley Research Program at Sheppard Pratt, Baltimore, MD, United States.
  • Yolken R; The Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, United States.
J Affect Disord ; 264: 221-226, 2020 03 01.
Article de En | MEDLINE | ID: mdl-32056754
ABSTRACT

BACKGROUND:

An atypical immune response to Epstein-Barr virus (EBV) infection has been associated with several complex diseases including schizophrenia. The etiology of MDD is unclear; host immune response to EBV infection could play a role.

METHODS:

We utilized solid phase immunoassays and western blots to measure antibodies to EBV virions, specific viral proteins, and 5 other herpesviruses in 87 individuals with MDD and 312 control individuals.

RESULTS:

Individuals with MDD had significantly reduced levels of reactivity to EBV Nuclear Antigen-1. Quantitative levels of antibodies to EBV virions and Viral Capsid Antigen did not differ between groups. Individuals with decreased levels of anti-Nuclear Antigen-1, or elevated levels of anti-virion had increased odds of being in the MDD group. The odds of MDD were elevated in individuals who had the combination of high levels of anti-virion and low levels of anti-Nuclear Antigen-1 (OR =13.6). Western blot analysis corroborated decreased reactivity to Nuclear Antigen-1 in the MDD group and revealed altered levels of antibodies to other EBV proteins. There was a trend towards decreased levels of antibodies to varicella virus in the group of individuals with MDD.

LIMITATIONS:

The MDD sample size was relatively small. There could be unmeasured factors that account for the association between MDD and the immune response to EBV.

CONCLUSIONS:

Individuals with MDD have altered levels and patterns of antibodies to EBV antigens. This atypical response could contribute to the immunopathology of MDD. Therapeutic interventions available for treatment of EBV infection could potentially be of benefit in MDD.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Herpèsvirus humain de type 4 / Trouble dépressif majeur Limites: Humans Langue: En Journal: J Affect Disord Année: 2020 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Herpèsvirus humain de type 4 / Trouble dépressif majeur Limites: Humans Langue: En Journal: J Affect Disord Année: 2020 Type de document: Article