Development of the clinical candidate PBD-C06, a humanized pGlu3-Aß-specific antibody against Alzheimer's disease with reduced complement activation.

Hettmann, Thore; Gillies, Stephen D; Kleinschmidt, Martin; Piechotta, Anke; Makioka, Koki; Lemere, Cynthia A; Schilling, Stephan; Rahfeld, Jens-Ulrich; Lues, Inge

Hettmann, Thore; Gillies, Stephen D; Kleinschmidt, Martin; Piechotta, Anke; Makioka, Koki; Lemere, Cynthia A; Schilling, Stephan; Rahfeld, Jens-Ulrich; Lues, Inge.

Affiliation

Hettmann T; Vivoryon Therapeutics AG, Weinbergweg 22, 06120, Halle (Saale), Germany.
Gillies SD; Provenance Biopharmaceuticals, 70 Bedford Rd, Carlisle, MA, 01741, USA.
Kleinschmidt M; Fraunhofer Institute for Cell Therapy and Immunology, Department Molecular Drug Biochemistry and Therapy, Weinbergweg 22, 06120, Halle (Saale), Germany.
Piechotta A; Fraunhofer Institute for Cell Therapy and Immunology, Department Molecular Drug Biochemistry and Therapy, Weinbergweg 22, 06120, Halle (Saale), Germany.
Makioka K; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.
Lemere CA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.
Schilling S; Vivoryon Therapeutics AG, Weinbergweg 22, 06120, Halle (Saale), Germany.
Rahfeld JU; Fraunhofer Institute for Cell Therapy and Immunology, Department Molecular Drug Biochemistry and Therapy, Weinbergweg 22, 06120, Halle (Saale), Germany.
Lues I; Vivoryon Therapeutics AG, Weinbergweg 22, 06120, Halle (Saale), Germany. jens-ulrich.rahfeld@izi.fraunhofer.de.

Sci Rep ; 10(1): 3294, 2020 02 24.

Article de En | MEDLINE | ID: mdl-32094456

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Acide pidolique / Activation du complément / Maladie d'Alzheimer / Anticorps monoclonaux humanisés / Immunothérapie Limites: Animals / Humans Langue: En Journal: Sci Rep Année: 2020 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: Royaume-Uni

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