TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.

Ennishi, Daisuke; Healy, Shannon; Bashashati, Ali; Saberi, Saeed; Hother, Christoffer; Mottok, Anja; Chan, Fong Chun; Chong, Lauren; Abraham, Libin; Kridel, Robert; Boyle, Merrill; Meissner, Barbara; Aoki, Tomohiro; Takata, Katsuyoshi; Woolcock, Bruce W; Viganò, Elena; Gold, Michael; Molday, Laurie L; Molday, Robert S; Telenius, Adele; Li, Michael Y; Wretham, Nicole; Dos Santos, Nancy; Wong, Mark; Viller, Natasja N; Uger, Robert A; Duns, Gerben; Baticados, Abigail; Madero, Angel; Bristow, Brianna N; Farinha, Pedro; Slack, Graham W; Ben-Neriah, Susana; Lai, Daniel; Zhang, Allen W; Salehi, Sohrab; Shulha, Hennady P; Chiu, Derek S; Mostafavi, Sara; Gerrie, Alina S; Huang, Da Wei; Rushton, Christopher; Villa, Diego; Sehn, Laurie H; Savage, Kerry J; Mungall, Andrew J; Weng, Andrew P; Bally, Marcel B; Morin, Ryan D; Cohen Freue, Gabriela V

Ennishi, Daisuke; Healy, Shannon; Bashashati, Ali; Saberi, Saeed; Hother, Christoffer; Mottok, Anja; Chan, Fong Chun; Chong, Lauren; Abraham, Libin; Kridel, Robert; Boyle, Merrill; Meissner, Barbara; Aoki, Tomohiro; Takata, Katsuyoshi; Woolcock, Bruce W; Viganò, Elena; Gold, Michael; Molday, Laurie L; Molday, Robert S; Telenius, Adele; Li, Michael Y; Wretham, Nicole; Dos Santos, Nancy; Wong, Mark; Viller, Natasja N; Uger, Robert A; Duns, Gerben; Baticados, Abigail; Madero, Angel; Bristow, Brianna N; Farinha, Pedro; Slack, Graham W; Ben-Neriah, Susana; Lai, Daniel; Zhang, Allen W; Salehi, Sohrab; Shulha, Hennady P; Chiu, Derek S; Mostafavi, Sara; Gerrie, Alina S; Huang, Da Wei; Rushton, Christopher; Villa, Diego; Sehn, Laurie H; Savage, Kerry J; Mungall, Andrew J; Weng, Andrew P; Bally, Marcel B; Morin, Ryan D; Cohen Freue, Gabriela V.

Affiliation

Ennishi D; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Healy S; Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan.
Bashashati A; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Saberi S; Molecular Oncology, British Columbia Cancer, Vancouver, British Columbia, Canada.
Hother C; Molecular Oncology, British Columbia Cancer, Vancouver, British Columbia, Canada.
Mottok A; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Chan FC; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Chong L; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
Abraham L; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Kridel R; Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada.
Boyle M; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Meissner B; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Aoki T; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Takata K; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Woolcock BW; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Viganò E; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Gold M; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Molday LL; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Molday RS; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Telenius A; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Li MY; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Wretham N; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Dos Santos N; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Wong M; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Viller NN; Department of Experimental Therapeutics, British Columbia Cancer, Vancouver, British Columbia, Canada.
Uger RA; Department of Experimental Therapeutics, British Columbia Cancer, Vancouver, British Columbia, Canada.
Duns G; Trillium Therapeutics Inc., Mississauga, Ontario, Canada.
Baticados A; Trillium Therapeutics Inc., Mississauga, Ontario, Canada.
Madero A; Trillium Therapeutics Inc., Mississauga, Ontario, Canada.
Bristow BN; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Farinha P; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Slack GW; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Ben-Neriah S; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Lai D; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Zhang AW; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Salehi S; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Shulha HP; Molecular Oncology, British Columbia Cancer, Vancouver, British Columbia, Canada.
Chiu DS; Molecular Oncology, British Columbia Cancer, Vancouver, British Columbia, Canada.
Mostafavi S; Molecular Oncology, British Columbia Cancer, Vancouver, British Columbia, Canada.
Gerrie AS; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Huang DW; Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
Rushton C; Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
Villa D; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Sehn LH; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Savage KJ; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mungall AJ; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Weng AP; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Bally MB; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Morin RD; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Cohen Freue GV; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer, Vancouver, British Columbia, Canada.

Nat Med ; 26(4): 577-588, 2020 04.

Article de En | MEDLINE | ID: mdl-32094924

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Transformation cellulaire néoplasique / Lymphome B diffus à grandes cellules / Thérapie moléculaire ciblée / Mutation perte de fonction / Protéines membranaires Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Adolescent / Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Pays/Région comme sujet: America do norte Langue: En Journal: Nat Med Sujet du journal: BIOLOGIA MOLECULAR / MEDICINA Année: 2020 Type de document: Article Pays d'affiliation: Canada

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