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Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics.
Bumbaca Yadav, Daniela; Reyes, Arthur E; Gupta, Priyanka; Vernes, Jean-Michel; Meng, Y Gloria; Schweiger, Michelle G; Stainton, Shannon L; Fuh, Germaine; Fielder, Paul J; Kamath, Amrita V; Shen, Ben-Quan.
Affiliation
  • Bumbaca Yadav D; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., South San Francisco, CA, USA.
  • Reyes AE; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., South San Francisco, CA, USA.
  • Gupta P; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., South San Francisco, CA, USA.
  • Vernes JM; Biochemical and Cellular Pharmacology Department, Genentech, Inc., South San Francisco, CA, USA.
  • Meng YG; Biochemical and Cellular Pharmacology Department, Genentech, Inc., South San Francisco, CA, USA.
  • Schweiger MG; Safety Assessment Department, Genentech, Inc., South San Francisco, CA, USA.
  • Stainton SL; Safety Assessment Department, Genentech, Inc., South San Francisco, CA, USA.
  • Fuh G; Antibody Engineering Department, Genentech, Inc., South San Francisco, CA, USA.
  • Fielder PJ; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., South San Francisco, CA, USA.
  • Kamath AV; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., South San Francisco, CA, USA.
  • Shen BQ; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., South San Francisco, CA, USA.
Pharmacol Res Perspect ; 8(2): e00573, 2020 04.
Article de En | MEDLINE | ID: mdl-32125783
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Facteur de croissance endothéliale vasculaire de type C / Anticorps monoclonaux Type d'étude: Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: Pharmacol Res Perspect Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Facteur de croissance endothéliale vasculaire de type C / Anticorps monoclonaux Type d'étude: Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: Pharmacol Res Perspect Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique