Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes.

Maluchenko, N V; Sultanov, D S; Kotova, E Yu; Kirpichnikov, M P; Studitsky, V M; Feofanov, A V

Maluchenko, N V; Sultanov, D S; Kotova, E Yu; Kirpichnikov, M P; Studitsky, V M; Feofanov, A V.

Affiliation

Maluchenko NV; Moscow State University, 119234, Moscow, Russia. mal_nat@mail.ru.
Sultanov DS; Fox Chase Cancer Center, Philadelphia, USA.
Kotova EY; Fox Chase Cancer Center, Philadelphia, USA.
Kirpichnikov MP; Moscow State University, 119234, Moscow, Russia.
Studitsky VM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Feofanov AV; Moscow State University, 119234, Moscow, Russia.

Dokl Biochem Biophys ; 489(1): 377-379, 2019 Nov.

Article de En | MEDLINE | ID: mdl-32130604

ABSTRACT

ABSTRACT

PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Histone / Nucléosomes / Poly (ADP-Ribose) polymerase-1 Limites: Animals Langue: En Journal: Dokl Biochem Biophys Sujet du journal: BIOFISICA / BIOQUIMICA Année: 2019 Type de document: Article Pays d'affiliation: Russie

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