Synthesis and anti-OXPHOS, antitumor activities of DLC modified spinosyn derivatives.

Ma, Da-You; Lai, Qin; Peng, Kun-Jian; Wang, Long-Long; Li, Zeng-Xia; Liu, Li-Jun; Luo, Zhi-Yong; Liu, Su-You

Ma, Da-You; Lai, Qin; Peng, Kun-Jian; Wang, Long-Long; Li, Zeng-Xia; Liu, Li-Jun; Luo, Zhi-Yong; Liu, Su-You.

Affiliation

Ma DY; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address: madayou@hotmail.com.
Lai Q; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Peng KJ; School of Life Sciences, Central South University, Changsha 410013, China.
Wang LL; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Li ZX; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Liu LJ; School of Life Sciences, Central South University, Changsha 410013, China.
Luo ZY; School of Life Sciences, Central South University, Changsha 410013, China.
Liu SY; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address: liusuyou@hotmail.com.

Bioorg Med Chem Lett ; 30(9): 127047, 2020 05 01.

Article de En | MEDLINE | ID: mdl-32139325

Sujet(s)
Mots clés

Antitumor activity; Delocalized lipophilic cation; Mitochondria; OXPHOS; Spinosyn

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phosphorylation oxydative / Macrolides / Mitochondries Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2020 Type de document: Article Pays de publication: Royaume-Uni

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