Monoterpenoid indole alkaloids from the stems of Kopsia officinalis.
Fitoterapia
; 143: 104547, 2020 Jun.
Article
de En
| MEDLINE
| ID: mdl-32173419
ABSTRACT
Five new indole alkaloids, kopsiofficines H-L (1-5), along with fourteen known alkaloids (6-19) were isolated from the stems of Kopsia officinalis. Their structures were elucidated by extensive NMR, mass spectroscopic analyses and comparison to the reported data. All the isolated compounds were evaluated their anti-inflammatory activities by inhibiting IL-1ß, PGE2 and TNF-α secretion in lipopolysaccharide (LPS)-activated RAW264.7 cells. Compounds 2, 3, 6, 7, 11, 12, 15, and 17 show significant anti-inflammatory activities. These results demonstrate pharmacodynamic substance basis of these folkloric claims.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tiges de plante
/
Apocynaceae
/
Alcaloïdes formés par condensation de sécologanine et de tryptamine
/
Anti-inflammatoires
Limites:
Animals
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Fitoterapia
Année:
2020
Type de document:
Article