Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Biochim Biophys Acta Mol Cell Res
; 1867(7): 118713, 2020 07.
Article
de En
| MEDLINE
| ID: mdl-32246948
ABSTRACT
WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential effects of excess WDR62 on proliferative growth remain undefined. Here, we demonstrate that glia specific overexpression of WDR62 in Drosophila larval brains resulted in increased cell size, over-proliferation and increased brain volume, without overt disruption of tissue organization. We further demonstrate WDR62 promoted over-proliferation and brain overgrowth by activating AURKA and pAKT signalling to increase MYC function in glial cells. Together these data suggest WDR62 normally functions in the glial lineage to activate oncogenic signalling networks, promoting proliferation and brain overgrowth.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteurs de transcription
/
Protéines de Drosophila
/
Protéines de liaison à l'ADN
/
Aurora kinase A
/
Protéines de tissu nerveux
Limites:
Animals
Langue:
En
Journal:
Biochim Biophys Acta Mol Cell Res
Année:
2020
Type de document:
Article
Pays d'affiliation:
Australie