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Prevalence and age distribution of pemphigus and pemphigoid diseases among paediatric patients in Germany.
Hübner, F; König, I R; Holtsche, M M; Zillikens, D; Linder, R; Schmidt, E.
Affiliation
  • Hübner F; Department of Dermatology, University of Lübeck, Lübeck, Germany.
  • König IR; Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.
  • Holtsche MM; Department of Dermatology, University of Lübeck, Lübeck, Germany.
  • Zillikens D; Department of Dermatology, University of Lübeck, Lübeck, Germany.
  • Linder R; Techniker Krankenkasse, Analytics & Insights, Hamburg, Germany.
  • Schmidt E; Department of Dermatology, University of Lübeck, Lübeck, Germany.
J Eur Acad Dermatol Venereol ; 34(11): 2600-2605, 2020 Nov.
Article de En | MEDLINE | ID: mdl-32289873
ABSTRACT

BACKGROUND:

Autoimmune bullous diseases are rare and mostly occur in adults. Several cases and small case series have been described in children, but no systematic study about the prevalence of autoimmune bullous diseases (AIBD) in children is available. PATIENTS AND

METHODS:

We analysed data of 1.7 million children insured in the largest German health insurance company based on the ICD-10-GM classification for the year 2015. Data were adjusted to the general German population based on the data of the Federal Statistical Office for the year 2015.

RESULTS:

The prevalence of AIBD was calculated to 101.1/million children in 2015, resulting in about 1351 patients below the age of 18 years in Germany. The highest prevalence of all AIBD was seen for pemphigus vulgaris (30.5/million children) followed by linear IgA disease (24.5/million children) and bullous pemphigoid (4.9/million children).

CONCLUSION:

Autoimmune bullous diseases in minors are scarce but should be taken into consideration in patients with pruritus and/or blisters and erosions on the skin and/or mucous membranes. Treatment is challenging, and due to the rarity of AIBD in minors, the management of these disorders in this patient population is best performed in specialized centres in a multidisciplinary approach, including paediatric dermatologists or dermatologists and paediatricians.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies auto-immunes / Pemphigoïde bulleuse / Pemphigus Type d'étude: Prevalence_studies / Risk_factors_studies Limites: Adolescent / Adult / Child / Humans Pays/Région comme sujet: Europa Langue: En Journal: J Eur Acad Dermatol Venereol Sujet du journal: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Année: 2020 Type de document: Article Pays d'affiliation: Allemagne

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies auto-immunes / Pemphigoïde bulleuse / Pemphigus Type d'étude: Prevalence_studies / Risk_factors_studies Limites: Adolescent / Adult / Child / Humans Pays/Région comme sujet: Europa Langue: En Journal: J Eur Acad Dermatol Venereol Sujet du journal: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Année: 2020 Type de document: Article Pays d'affiliation: Allemagne