Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.

Sun, Lin; Dick, Alexej; Meuser, Megan E; Huang, Tianguang; Zalloum, Waleed A; Chen, Chin-Ho; Cherukupalli, Srinivasulu; Xu, Shujing; Ding, Xiao; Gao, Ping; Kang, Dongwei; De Clercq, Erik; Pannecouque, Christophe; Cocklin, Simon; Lee, Kuo-Hsiung; Liu, Xinyong; Zhan, Peng

Sun, Lin; Dick, Alexej; Meuser, Megan E; Huang, Tianguang; Zalloum, Waleed A; Chen, Chin-Ho; Cherukupalli, Srinivasulu; Xu, Shujing; Ding, Xiao; Gao, Ping; Kang, Dongwei; De Clercq, Erik; Pannecouque, Christophe; Cocklin, Simon; Lee, Kuo-Hsiung; Liu, Xinyong; Zhan, Peng.

Affiliation

Sun L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Dick A; Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, United States.
Meuser ME; Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, United States.
Huang T; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Zalloum WA; Department of Pharmacy, Faculty of Health Science, American University of Madaba, P.O Box 2882, Amman 11821, Jordan.
Chen CH; Duke University Medical Center, Surgical Oncology Research Facility, Box 2926, Durham, North Carolina 27710, United States.
Cherukupalli S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Xu S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Ding X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Gao P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
De Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Cocklin S; Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, United States.
Lee KH; Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, People's Republic of China.

J Med Chem ; 63(9): 4790-4810, 2020 05 14.

Article de En | MEDLINE | ID: mdl-32298111

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénylalanine / Sulfonamides / VIH-1 (Virus de l'Immunodéficience Humaine de type 1) / Agents antiVIH / Protéines de capside Limites: Animals / Female / Humans / Male Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2020 Type de document: Article

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