The pathological role of ferroptosis in ischemia/reperfusion-related injury.
Zool Res
; 41(3): 220-230, 2020 May 18.
Article
de En
| MEDLINE
| ID: mdl-32314558
ABSTRACT
Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lésion d'ischémie-reperfusion
/
Ferroptose
Limites:
Animals
Langue:
En
Journal:
Zool Res
Année:
2020
Type de document:
Article
Pays d'affiliation:
Chine