Regulation of Humoral Immune Responses and B Cell Tolerance by the IgM Fc Receptor (FcµR).
Adv Exp Med Biol
; 1254: 75-86, 2020.
Article
de En
| MEDLINE
| ID: mdl-32323271
ABSTRACT
Immunoglobulin (Ig) M is the first antibody isotype produced during an immune response and is critical for host defense against infections. Recent studies have revealed that IgM also plays an important role in immune regulation and immunological tolerance. Mice lacking secretory IgM not only exhibit impaired production of antigen-specific IgG and are more susceptible to bacterial and viral infections, but also produce autoantibodies and are prone to develop autoimmune diseases. For many years, IgM has been thought to function predominantly by binding to antigen and activating complement (C') system. It is now clear that IgM can also elicit its function through the IgM Fc receptor (FcµR). In this chapter, we will review the role of FcµR in B cell development, maturation, survival and activation, antibody production, host defense against bacterial and viral infections, and B cell tolerance. We will also discuss the relative contribution of IgM-C' and IgM-FcµR pathways in humoral immune responses. Finally, we will discuss the possible involvement of FcµR in human chronic lymphocytic leukemia.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes B
/
Récepteur Fc
/
Immunité humorale
/
Tolérance immunitaire
Limites:
Animals
/
Humans
Langue:
En
Journal:
Adv Exp Med Biol
Année:
2020
Type de document:
Article
Pays d'affiliation:
Chine