STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Mol Syst Biol
; 16(4): e9247, 2020 04.
Article
de En
| MEDLINE
| ID: mdl-32323921
ABSTRACT
Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential biomarkers for risk stratification, by utilizing a gene co-expression network of transcriptomics data in addition to laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation of oxidative phosphorylation (OXPHOS) in PCa on the transcriptomic level and up-regulation of the TCA cycle/OXPHOS on the proteomic level, which is inversely correlated to STAT3 expression. We hereby identify gene expression of pyruvate dehydrogenase kinase 4 (PDK4), a key regulator of the TCA cycle, as a promising independent prognostic marker in PCa. PDK4 predicts disease recurrence independent of diagnostic risk factors such as grading, staging, and PSA level. Therefore, low PDK4 is a promising marker for PCa with dismal prognosis.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de la prostate
/
Analyse de profil d'expression de gènes
/
Protéomique
/
Facteur de transcription STAT-3
/
Pyruvate dehydrogenase acetyl-transferring kinase
/
Récidive tumorale locale
/
Tumeurs expérimentales
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Animals
/
Humans
/
Male
Langue:
En
Journal:
Mol Syst Biol
Sujet du journal:
BIOLOGIA MOLECULAR
/
BIOTECNOLOGIA
Année:
2020
Type de document:
Article
Pays d'affiliation:
Autriche