Determination of the melanocortin-4 receptor structure identifies Ca<sup>2+</sup> as a cofactor for ligand binding.

Yu, Jing; Gimenez, Luis E; Hernandez, Ciria C; Wu, Yiran; Wein, Ariel H; Han, Gye Won; McClary, Kyle; Mittal, Sanraj R; Burdsall, Kylie; Stauch, Benjamin; Wu, Lijie; Stevens, Sophia N; Peisley, Alys; Williams, Savannah Y; Chen, Valerie; Millhauser, Glenn L; Zhao, Suwen; Cone, Roger D; Stevens, Raymond C

Determination of the melanocortin-4 receptor structure identifies Ca²⁺ as a cofactor for ligand binding.

Yu, Jing; Gimenez, Luis E; Hernandez, Ciria C; Wu, Yiran; Wein, Ariel H; Han, Gye Won; McClary, Kyle; Mittal, Sanraj R; Burdsall, Kylie; Stauch, Benjamin; Wu, Lijie; Stevens, Sophia N; Peisley, Alys; Williams, Savannah Y; Chen, Valerie; Millhauser, Glenn L; Zhao, Suwen; Cone, Roger D; Stevens, Raymond C.

Affiliation

Yu J; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.
Gimenez LE; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Hernandez CC; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Wu Y; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Wein AH; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Han GW; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.
McClary K; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Mittal SR; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Burdsall K; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Stauch B; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Wu L; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Stevens SN; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Peisley A; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.
Williams SY; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.
Chen V; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Millhauser GL; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Zhao S; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Cone RD; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Stevens RC; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.

Science ; 368(6489): 428-433, 2020 04 24.

Article de En | MEDLINE | ID: mdl-32327598

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Calcium / Récepteurs couplés aux protéines G / Récepteur de la mélanocortine de type 4 Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Science Année: 2020 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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