Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions.

Chen, Yuan; Ma, Fang; Jones, Nicholas S; Yoshida, Kenta; Chiang, Po-Chang; Durk, Matthew R; Wright, Matthew R; Jin, Jin Yan; Chinn, Leslie W

Chen, Yuan; Ma, Fang; Jones, Nicholas S; Yoshida, Kenta; Chiang, Po-Chang; Durk, Matthew R; Wright, Matthew R; Jin, Jin Yan; Chinn, Leslie W.

Affiliation

Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Ma F; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Jones NS; Department of Clinical Science, Genentech, Inc., South San Francisco, California, USA.
Yoshida K; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Chiang PC; Department of Pharmaceutical Science, Genentech, Inc., South San Francisco, California, USA.
Durk MR; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Wright MR; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Jin JY; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Chinn LW; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.

CPT Pharmacometrics Syst Pharmacol ; 9(6): 332-341, 2020 06.

Article de En | MEDLINE | ID: mdl-32383787

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pipérazines / Pyridones / Polypeptide C de transport d'anions organiques / Cytochrome P-450 CYP3A / Inhibiteurs du cytochrome P-450 CYP3A / Membre-2 de la sous-famille G des transporteurs à cassette liant l'ATP / Intestins / Foie / Modèles biologiques / Protéines tumorales Type d'étude: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Animals / Humans Langue: En Journal: CPT Pharmacometrics Syst Pharmacol Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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