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Quality of life and the negative impact of comorbidities in long-term colorectal cancer survivors: a population-based comparison.
Pate, Amy; Lowery, Jan; Kilbourn, Kristin; Blatchford, Patrick J; McNulty, Monica; Risendal, Betsy.
Affiliation
  • Pate A; Preventive Medicine Residency, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
  • Lowery J; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.
  • Kilbourn K; Department of Psychology, University of Colorado Denver, Denver, CO, USA.
  • Blatchford PJ; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
  • McNulty M; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
  • Risendal B; Department of Community and Behavioral Health, Colorado School of Public Health, 13001 E. 17th Place, Bldg 500, MS F538, Aurora, CO, 80045, USA. betsy.risendal@cuanschutz.edu.
J Cancer Surviv ; 14(5): 653-659, 2020 10.
Article de En | MEDLINE | ID: mdl-32394045
ABSTRACT

PURPOSE:

Colorectal cancer (CRC) is the third most common cancer in the USA. The objective of this study was to compare quality of life (QoL) across long-term colorectal cancer survivors and unaffected matched controls while adjusting for comorbidities.

METHODS:

The National Cancer Institute (NCI)-funded Colon Cancer Family Registry (CCFR) was used to randomly select and recruit CRC survivors (≥ 5 years from diagnosis) and matched controls for a cross-sectional survey. Nine geographically diverse sites in the USA from the CCFR participated in the study. Telephone interviews were conducted using computer-assisted methods to assess QoL.

RESULTS:

A total of 403 cases and 401 controls were included in the final sample. Unadjusted comparison revealed no significant difference between CRC survivors and controls with respect to measures of fatigue, social, emotional, functional, and physical well-being. Multivariate logistic regression revealed that case status had a significant negative influence on colorectal cancer-specific QoL measures. Higher comorbidity indices had a significant negative influence on overall QoL regardless of case status.

CONCLUSIONS:

Quality of life among long-term CRC survivors is similar to control subjects, with the exception of worse CRC-specific QoL measures. Higher comorbidity indices were independently associated with poor QoL for both cases and controls. IMPLICATIONS FOR CANCER SURVIVORS Survivors and healthcare providers should be aware that long-term QoL is comparable to the general population; however, there is potential that digestive tract-specific issues may persist.
Sujet(s)
Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Qualité de vie / Tumeurs colorectales / Enregistrements / Survivants du cancer Type d'étude: Clinical_trials / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Aspects: Patient_preference Limites: Aged / Female / Humans / Male / Middle aged Pays/Région comme sujet: America do norte Langue: En Journal: J Cancer Surviv Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Qualité de vie / Tumeurs colorectales / Enregistrements / Survivants du cancer Type d'étude: Clinical_trials / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Aspects: Patient_preference Limites: Aged / Female / Humans / Male / Middle aged Pays/Région comme sujet: America do norte Langue: En Journal: J Cancer Surviv Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique