Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.

Clegg, Michael A; Bamborough, Paul; Chung, Chun-Wa; Craggs, Peter D; Gordon, Laurie; Grandi, Paola; Leveridge, Melanie; Lindon, Matthew; Liwicki, Gemma M; Michon, Anne-Marie; Molnar, Judit; Rioja, Inmaculada; Soden, Peter E; Theodoulou, Natalie H; Werner, Thilo; Tomkinson, Nicholas C O; Prinjha, Rab K; Humphreys, Philip G

Clegg, Michael A; Bamborough, Paul; Chung, Chun-Wa; Craggs, Peter D; Gordon, Laurie; Grandi, Paola; Leveridge, Melanie; Lindon, Matthew; Liwicki, Gemma M; Michon, Anne-Marie; Molnar, Judit; Rioja, Inmaculada; Soden, Peter E; Theodoulou, Natalie H; Werner, Thilo; Tomkinson, Nicholas C O; Prinjha, Rab K; Humphreys, Philip G.

Affiliation

Clegg MA; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Bamborough P; WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
Chung CW; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Craggs PD; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Gordon L; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Grandi P; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Leveridge M; Cellzome GmbH, R&D MST GlaxoSmithKline, Meyerhofstrasse 1 69117 Heidelberg, Germany.
Lindon M; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Liwicki GM; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Michon AM; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Molnar J; Cellzome GmbH, R&D MST GlaxoSmithKline, Meyerhofstrasse 1 69117 Heidelberg, Germany.
Rioja I; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Soden PE; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Theodoulou NH; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Werner T; GlaxoSmithKline R&D, Stevenage SG1 2NY, Hertfordshire, United Kingdom.
Tomkinson NCO; WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
Prinjha RK; Cellzome GmbH, R&D MST GlaxoSmithKline, Meyerhofstrasse 1 69117 Heidelberg, Germany.
Humphreys PG; WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.

J Med Chem ; 63(11): 5816-5840, 2020 06 11.

Article de En | MEDLINE | ID: mdl-32410449

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyridazines / Facteurs de transcription / Protéines chromosomiques nonhistones / Lysine Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2020 Type de document: Article Pays d'affiliation: Royaume-Uni Pays de publication: États-Unis d'Amérique

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