Seasonal distribution of attacks in aquaporin-4 antibody disease and myelin-oligodendrocyte antibody disease.
J Neurol Sci
; 415: 116881, 2020 Aug 15.
Article
de En
| MEDLINE
| ID: mdl-32428758
ABSTRACT
BACKGROUND:
Seasonal variation in incidence and exacerbations has been reported for neuroinflammatory conditions such as multiple sclerosis and acute disseminated encephalomyelitis (ADEM). It is unknown whether seasonality also influences aquaporin-4 antibody (AQP4-Ab) disease and myelin-oligodendrocyte antibody (MOG-Ab) disease.OBJECTIVE:
We examined the seasonal distribution of attacks in AQP4-Ab disease and MOG-Ab disease.METHODS:
Observational study using data prospectively recorded from three cohorts in the United Kingdom.RESULTS:
There was no clear seasonal variation in AQP4-Ab or MOG-Ab attacks for either the onset attack nor subsequent relapses. In both groups, the proportion of attacks manifesting with each of the main phenotypes (optic neuritis, transverse myelitis, ADEM/ADEM-like) appeared stable across the year. This study is the first to examine seasonal distribution of MOG-Ab attacks and the largest in AQP4-Ab disease so far.CONCLUSION:
Lack of seasonal distribution in AQP4-Ab and MOG-Ab disease may argue against environment factors playing a role in the aetiopathogenesis of these conditions.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Aquaporines
/
Gaine de myéline
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
J Neurol Sci
Année:
2020
Type de document:
Article
Pays d'affiliation:
Royaume-Uni