The Diverse Involvement of Cigarette Smoking in Pancreatic Cancer Development and Prognosis.
Pancreas
; 49(5): 612-620, 2020.
Article
de En
| MEDLINE
| ID: mdl-32433397
ABSTRACT
Despite extensive research in the pathogenesis, early detection, and therapeutic approaches of pancreatic ductal adenocarcinoma (PDAC), it remains a devastating and incurable disease. As the global incidence and prevalence of PDAC continue to rise, there is a pressing need to place strong emphasis on its prevention. Although it is widely recognized that cigarette smoking, a potentially modifiable risk factor, has been linked to PDAC development, its contribution to prognosis is still uncertain. Moreover, the mechanistic pathways of PDAC progression secondary to smoking are various and lack a summative narration. Herein, we update and summarize the direct and indirect roles cigarette smoking plays on PDAC development, review literature to conclude the impact cigarette smoking has on prognosis, and postulate a comprehensive mechanism for cigarette smoking-induced PDAC.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du pancréas
/
Carcinome du canal pancréatique
/
Fumer des cigares
/
Fumer des cigarettes
Limites:
Humans
Langue:
En
Journal:
Pancreas
Sujet du journal:
GASTROENTEROLOGIA
Année:
2020
Type de document:
Article