Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response.

Mendes, Bárbara B; Gómez-Florit, Manuel; Osório, Hugo; Vilaça, Adriana; Domingues, Rui M A; Reis, Rui L; Gomes, Manuela E

Mendes, Bárbara B; Gómez-Florit, Manuel; Osório, Hugo; Vilaça, Adriana; Domingues, Rui M A; Reis, Rui L; Gomes, Manuela E.

Affiliation

Mendes BB; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães, Portugal. megomes@i3bs.uminho.pt rui.domingues@i3bs.uminho.pt.

Chem Commun (Camb) ; 56(50): 6882-6885, 2020 Jun 25.

Article de En | MEDLINE | ID: mdl-32435790

ABSTRACT

ABSTRACT

The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.

Sujet(s)

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cellules souches / Cellulose / Tissu adipeux / Nanoparticules / Couronne de protéines Limites: Humans Langue: En Journal: Chem Commun (Camb) Sujet du journal: QUIMICA Année: 2020 Type de document: Article

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google