Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.

Arshad, Usman; Pertinez, Henry; Box, Helen; Tatham, Lee; Rajoli, Rajith K R; Curley, Paul; Neary, Megan; Sharp, Joanne; Liptrott, Neill J; Valentijn, Anthony; David, Christopher; Rannard, Steve P; O'Neill, Paul M; Aljayyoussi, Ghaith; Pennington, Shaun H; Ward, Stephen A; Hill, Andrew; Back, David J; Khoo, Saye H; Bray, Patrick G; Biagini, Giancarlo A; Owen, Andrew

Arshad, Usman; Pertinez, Henry; Box, Helen; Tatham, Lee; Rajoli, Rajith K R; Curley, Paul; Neary, Megan; Sharp, Joanne; Liptrott, Neill J; Valentijn, Anthony; David, Christopher; Rannard, Steve P; O'Neill, Paul M; Aljayyoussi, Ghaith; Pennington, Shaun H; Ward, Stephen A; Hill, Andrew; Back, David J; Khoo, Saye H; Bray, Patrick G; Biagini, Giancarlo A; Owen, Andrew.

Affiliation

Arshad U; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Pertinez H; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Box H; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Tatham L; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Rajoli RKR; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Curley P; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Neary M; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Sharp J; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Liptrott NJ; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Valentijn A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
David C; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Rannard SP; Department of Chemistry, University of Liverpool, Liverpool, UK.
O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool, UK.
Aljayyoussi G; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Centre for Drugs and Diagnostics, Liverpool, UK.
Pennington SH; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Centre for Drugs and Diagnostics, Liverpool, UK.
Ward SA; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Centre for Drugs and Diagnostics, Liverpool, UK.
Hill A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Back DJ; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Khoo SH; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Bray PG; Pat Bray Electrical, Wigan, UK.
Biagini GA; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Centre for Drugs and Diagnostics, Liverpool, UK.
Owen A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.

Clin Pharmacol Ther ; 108(4): 775-790, 2020 10.

Article de En | MEDLINE | ID: mdl-32438446

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antiviraux / Pneumopathie virale / Systèmes de délivrance de médicaments / Infections à coronavirus / Repositionnement des médicaments / Betacoronavirus Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Clin Pharmacol Ther Année: 2020 Type de document: Article Pays d'affiliation: Royaume-Uni Pays de publication: États-Unis d'Amérique

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