Percussion assisted radiation therapy in Hodgkin lymphoma allows a marked reduction in heart dose.
Radiother Oncol
; 152: 163-168, 2020 11.
Article
de En
| MEDLINE
| ID: mdl-32448409
ABSTRACT
BACKGROUND AND PURPOSE:
Early-stage Hodgkin lymphoma (HL) is a highly curable disease but the treatment can induce late complications many years later. Irradiation of the healthy heart is inevitable during radiation treatment of mediastinal sites. We developed a novel method to induce a prolonged apnea-like state that can help decrease the dose to organs at risk during radiation therapy. We present the results of the first 8 HL patients treated routinely with percussion assisted radiation therapy (PART) in our clinic. MATERIAL ANDMETHODS:
We used a newly developed high-frequency non-invasive ventilation system to suppress respiratory motion for prolonged periods and push the heart away from the treated volume.RESULTS:
All 8 patients were able to rapidly learn the technique and had an advantage to be treated by PART. We lowered the mean heart dose by an average of 3 Gy with similar target coverage compared to a classical free breathing treatment plan. They were all treated for 15 radiotherapy sessions by PART without any notable side effects.CONCLUSIONS:
Percussion assisted radiation therapy can be used routinely to reduce the dose to the heart in Hodgkin lymphoma.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lésions radiques
/
Maladie de Hodgkin
/
Radiothérapie conformationnelle avec modulation d'intensité
Type d'étude:
Etiology_studies
Limites:
Humans
Langue:
En
Journal:
Radiother Oncol
Année:
2020
Type de document:
Article
Pays d'affiliation:
Suisse