Progressive Multifocal Leukoencephalopathy during Tocilizumab Treatment for Rheumatoid Arthritis.
Intern Med
; 59(16): 2053-2059, 2020 Aug 15.
Article
de En
| MEDLINE
| ID: mdl-32448834
ABSTRACT
A 61-year-old woman was diagnosed with rheumatoid arthritis 12 years ago and received multiple treatment regimens before achieving symptomatic stability with methotrexate plus tocilizumab, a humanized monoclonal antibody against the IL-6 receptor, about 2 years prior to the current presentation. Sixteen months after tocilizumab initiation, she exhibited dysarthria and disorientation; five months later, she was hospitalized with movement difficulties. Her neurological symptoms deteriorated thereafter, accompanied by enlarged cerebral white matter lesions on magnetic resonance imaging. A biopsy of the right frontal lesion confirmed progressive multifocal leukoencephalopathy (PML). While several therapeutic monoclonal antibodies have been linked to PML, this is the first case associated with tocilizumab.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polyarthrite rhumatoïde
/
Leucoencéphalopathie multifocale progressive
/
Anticorps monoclonaux humanisés
Type d'étude:
Diagnostic_studies
Limites:
Female
/
Humans
/
Middle aged
Langue:
En
Journal:
Intern Med
Sujet du journal:
MEDICINA INTERNA
Année:
2020
Type de document:
Article
Pays d'affiliation:
Japon