Immuno-SPECT/PET imaging with radioiodinated anti-PD-L1 antibody to evaluate PD-L1 expression in immune-competent murine models and PDX model of lung adenocarcinoma.

Wen, Xuejun; Shi, Changrong; Zhao, Liang; Yao, Lanlin; Xu, Duo; Lin, Xiaoru; Su, Xinhui; Liu, Ting; Zhuang, Rongqiang; Lin, Qin; Chen, Haojun; Guo, Zhide; Zhang, Xianzhong

Wen, Xuejun; Shi, Changrong; Zhao, Liang; Yao, Lanlin; Xu, Duo; Lin, Xiaoru; Su, Xinhui; Liu, Ting; Zhuang, Rongqiang; Lin, Qin; Chen, Haojun; Guo, Zhide; Zhang, Xianzhong.

Affiliation

Wen X; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China.
Shi C; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China.
Zhao L; Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361103, China; Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361103, China.
Yao L; Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361103, China.
Xu D; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China.
Lin X; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China.
Su X; Zhongshan Hospital Affiliated to Xiamen University, Hubin South Road, Xiamen 361004, China.
Liu T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China.
Zhuang R; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China.
Lin Q; Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361103, China. Electronic address: linqin05@163.com.
Chen H; Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361103, China. Electronic address: leochen0821@foxmail.com.
Guo Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China. Electronic address: gzd666888@xmu.edu.cn.
Zhang X; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen 361102, China. Electronic address: zhangxzh@xmu.edu.cn.

Nucl Med Biol ; 86-87: 44-51, 2020.

Article de En | MEDLINE | ID: mdl-32474281

Sujet(s)
Mots clés

Immune-competent murine model; Immuno-SPECT/PET imaging; PD-L1 antibody; PDX model; Radioiodinated strategy

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Mélanome expérimental / Régulation de l'expression des gènes tumoraux / Tomographie par émission monophotonique / Immunoconjugués / Tomographie par émission de positons / Antigène CD274 / Adénocarcinome pulmonaire Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Nucl Med Biol Sujet du journal: BIOLOGIA / MEDICINA NUCLEAR Année: 2020 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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