Desaturase specificity is controlled by the physicochemical properties of a single amino acid residue in the substrate binding tunnel.

Bucek, Ales; Vazdar, Mario; Tupec, Michal; Svatos, Ales; Pichová, Iva

Bucek, Ales; Vazdar, Mario; Tupec, Michal; Svatos, Ales; Pichová, Iva.

Affiliation

Bucek A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n., 2, 166 10 Prague 6, Czech Republic.
Vazdar M; Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, 904-0495 Okinawa, Japan.
Tupec M; Division of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, Croatia.
Svatos A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n., 2, 166 10 Prague 6, Czech Republic.
Pichová I; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n., 2, 166 10 Prague 6, Czech Republic.

Comput Struct Biotechnol J ; 18: 1202-1209, 2020.

Article de En | MEDLINE | ID: mdl-32542106

Mots clés

Acyl-CoA desaturase; Bombyx mori; Enzymatic specificity; Manduca sexta; Molecular dynamics simulations; Protein engineering

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Prognostic_studies Langue: En Journal: Comput Struct Biotechnol J Année: 2020 Type de document: Article Pays d'affiliation: République tchèque Pays de publication: Pays-Bas

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