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In Vitro Modeling of Human Brain Arteriovenous Malformation for Endovascular Simulation and Flow Analysis.
Kaneko, Naoki; Ullman, Henrik; Ali, Fadil; Berg, Philipp; Ooi, Yinn Cher; Tateshima, Satoshi; Colby, Geoffrey P; Komuro, Yutaro; Hu, Peng; Khatibi, Kasra; Ponce Mejia, Lucido L; Szeder, Viktor; Nour, May; Guo, Lea; Chien, Aichi; Vinuela, Fernando; Nemoto, Shigeru; Mashiko, Toshihiro; Sehara, Yoshihide; Hinman, Jason D; Duckwiler, Gary; Jahan, Reza.
Affiliation
  • Kaneko N; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA. Electronic address: nkaneko@ucla.edu.
  • Ullman H; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Ali F; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Berg P; Research Campus STIMULATE, University of Magdeburg, Magdeburg, Germany.
  • Ooi YC; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Tateshima S; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Colby GP; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Komuro Y; Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Hu P; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Khatibi K; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Ponce Mejia LL; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Szeder V; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Nour M; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA; Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Guo L; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Chien A; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Vinuela F; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Nemoto S; Kanto Rosai Hospital, Kawasaki, Japan.
  • Mashiko T; Department of Neurosurgery, Jichi Medical University, Shimotsuke, Japan.
  • Sehara Y; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
  • Hinman JD; Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Duckwiler G; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Jahan R; Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
World Neurosurg ; 141: e873-e879, 2020 09.
Article de En | MEDLINE | ID: mdl-32565379
ABSTRACT

BACKGROUND:

Current in vitro models for human brain arteriovenous malformation (AVM) analyzing the efficacy of embolic materials or flow conditions are limited by a lack of realistic anatomic features of complex AVM nidus. The purpose of this study was to evaluate a newly developed in vitro AVM model for embolic material testing, preclinical training, and flow analysis.

METHODS:

Three-dimensional (3D) images of the AVM nidus were extracted from 3D rotational angiography from a patient. Inner vascular mold was printed using a 3D printer, coated with polydimethylsiloxanes, and then was removed by acetone, leaving a hollow AVM model. Injections of liquid embolic material and 4-dimensional (4D) flow magnetic resonance imaging (MRI) were performed using the AVM models. Additionally, computational fluid dynamics analysis was performed to examine the flow volume rate as compared with 4D flow MRI.

RESULTS:

The manufacture of 3D in vitro AVM models delivers a realistic representation of human nidus vasculature and complexity derived from patients. The injection of liquid embolic agents performed in the in vitro model successfully replicated real-life treatment conditions. The model simulated the plug and push technique before penetration of the liquid embolic material into the AVM nidus. The 4D flow MRI results were comparable to computational fluid dynamics analysis.

CONCLUSIONS:

An in vitro human brain AVM model with realistic geometric complexities of nidus was successfully created using 3D printing technology. This AVM model offers a useful tool for training of embolization techniques and analysis of hemodynamics analysis, and development of new devices and materials.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Malformations artérioveineuses intracrâniennes / Embolisation thérapeutique / Procédures endovasculaires / Modèles neurologiques Limites: Humans Langue: En Journal: World Neurosurg Sujet du journal: NEUROCIRURGIA Année: 2020 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Malformations artérioveineuses intracrâniennes / Embolisation thérapeutique / Procédures endovasculaires / Modèles neurologiques Limites: Humans Langue: En Journal: World Neurosurg Sujet du journal: NEUROCIRURGIA Année: 2020 Type de document: Article