Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease.
Mol Nutr Food Res
; 65(5): e2000023, 2021 03.
Article
de En
| MEDLINE
| ID: mdl-32583604
ABSTRACT
As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, ß-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Consommation d'alcool
/
Stéatose hépatique alcoolique
/
Microbiome gastro-intestinal
Limites:
Animals
/
Humans
Langue:
En
Journal:
Mol Nutr Food Res
Sujet du journal:
CIENCIAS DA NUTRICAO
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique