100 Years Later, What Is New in Glycerol Bioproduction?
Trends Biotechnol
; 38(8): 907-916, 2020 08.
Article
de En
| MEDLINE
| ID: mdl-32584768
ABSTRACT
Industrial production of glycerol by yeast, which began during WWI in the so-called Neuberg fermentation, was the first example of metabolic engineering. However, this process, based on bisulfite addition to fermentation liquid, has many drawbacks and was replaced by other methods of glycerol production. Osmotolerant yeasts and other microorganisms that do not require addition of bisulfite to steer cellular metabolism towards glycerol synthesis have been discovered or engineered. Because the glycerol market is expected to reach 5 billion US$ by 2024, microbial fermentation may again become a promising way to produce glycerol. This review summarizes some problems and perspectives on the production of glycerol by natural or engineered eukaryotic and prokaryotic microorganisms.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Saccharomyces cerevisiae
/
Métabolisme glucidique
/
Génie métabolique
/
Glycérol
Limites:
Humans
Langue:
En
Journal:
Trends Biotechnol
Année:
2020
Type de document:
Article
Pays d'affiliation:
Ukraine