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COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Chua, Robert Lorenz; Lukassen, Soeren; Trump, Saskia; Hennig, Bianca P; Wendisch, Daniel; Pott, Fabian; Debnath, Olivia; Thürmann, Loreen; Kurth, Florian; Völker, Maria Theresa; Kazmierski, Julia; Timmermann, Bernd; Twardziok, Sven; Schneider, Stefan; Machleidt, Felix; Müller-Redetzky, Holger; Maier, Melanie; Krannich, Alexander; Schmidt, Sein; Balzer, Felix; Liebig, Johannes; Loske, Jennifer; Suttorp, Norbert; Eils, Jürgen; Ishaque, Naveed; Liebert, Uwe Gerd; von Kalle, Christof; Hocke, Andreas; Witzenrath, Martin; Goffinet, Christine; Drosten, Christian; Laudi, Sven; Lehmann, Irina; Conrad, Christian; Sander, Leif-Erik; Eils, Roland.
Affiliation
  • Chua RL; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Lukassen S; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Trump S; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Hennig BP; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Wendisch D; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Pott F; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Debnath O; Berlin Institute of Health (BIH), Berlin, Germany.
  • Thürmann L; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Kurth F; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Völker MT; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Kazmierski J; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Timmermann B; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany.
  • Twardziok S; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Schneider S; Berlin Institute of Health (BIH), Berlin, Germany.
  • Machleidt F; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Müller-Redetzky H; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Maier M; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Krannich A; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Schmidt S; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Balzer F; Institute of Virology, University Hospital Leipzig, Leipzig, Germany.
  • Liebig J; Clinical Study Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Loske J; Clinical Study Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Suttorp N; Department of Anestesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Eils J; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Ishaque N; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Liebert UG; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • von Kalle C; German Center for Lung Research (DZL), Berlin, Germany.
  • Hocke A; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Witzenrath M; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Goffinet C; Institute of Virology, University Hospital Leipzig, Leipzig, Germany.
  • Drosten C; Clinical Study Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Laudi S; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Lehmann I; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Conrad C; German Center for Lung Research (DZL), Berlin, Germany.
  • Sander LE; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.
  • Eils R; Berlin Institute of Health (BIH), Berlin, Germany.
Nat Biotechnol ; 38(8): 970-979, 2020 08.
Article de En | MEDLINE | ID: mdl-32591762
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pneumopathie virale / Appareil respiratoire / Infections à coronavirus / Analyse sur cellule unique / Transcriptome Type d'étude: Observational_studies / Risk_factors_studies Limites: Adult / Aged / Female / Humans / Male / Middle aged Langue: En Journal: Nat Biotechnol Sujet du journal: BIOTECNOLOGIA Année: 2020 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pneumopathie virale / Appareil respiratoire / Infections à coronavirus / Analyse sur cellule unique / Transcriptome Type d'étude: Observational_studies / Risk_factors_studies Limites: Adult / Aged / Female / Humans / Male / Middle aged Langue: En Journal: Nat Biotechnol Sujet du journal: BIOTECNOLOGIA Année: 2020 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique