Role of Inflammation in Pathophysiology of Colonic Disease: An Update.
Int J Mol Sci
; 21(13)2020 Jul 03.
Article
de En
| MEDLINE
| ID: mdl-32635383
ABSTRACT
Diseases of the colon are a big health burden in both men and women worldwide ranging from acute infection to cancer. Environmental and genetic factors influence disease onset and outcome in multiple colonic pathologies. The importance of inflammation in the onset, progression and outcome of multiple colonic pathologies is gaining more traction as the evidence from recent research is considered. In this review, we provide an update on the literature to understand how genetics, diet, and the gut microbiota influence the crosstalk between immune and nonimmune cells resulting in inflammation observed in multiple colonic pathologies. Specifically, we focus on four colonic diseases two of which have a more established association with inflammation (inflammatory bowel disease and colorectal cancer) while the other two have a less understood relationship with inflammation (diverticular disease and irritable bowel syndrome).
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Colite
/
Maladies du côlon
Type d'étude:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Animals
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Int J Mol Sci
Année:
2020
Type de document:
Article
Pays d'affiliation:
Nouvelle-Zélande