The role of neuropeptides in learning: Insights from C. elegans.
Int J Biochem Cell Biol
; 125: 105801, 2020 08.
Article
de En
| MEDLINE
| ID: mdl-32652305
ABSTRACT
Learning is critical for survival as it provides the capacity to adapt to a changing environment. At the molecular and cellular level, learning leads to alterations within neural circuits that include synaptic rewiring and synaptic plasticity. These changes are mediated by signalling molecules known as neuromodulators. One such class of neuromodulators are neuropeptides, a diverse group of short peptides that primarily act through G protein-coupled receptors. There has been substantial progress in recent years on dissecting the role of neuropeptides in learning circuits using compact yet powerful invertebrate model systems. We will focus on insights gained using the nematode Caenorhabditis elegans, with its unparalleled genetic tractability, compact nervous system of â¼300 neurons, high level of conservation with mammalian systems and amenability to a suite of behavioural analyses. Specifically, we will summarise recent discoveries in C. elegans on the role of neuropeptides in non-associative and associative learning.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Apprentissage associatif
/
Comportement animal
/
Neuropeptides
/
Transduction du signal
/
Caenorhabditis elegans
/
Apprentissage
/
Neurones
Limites:
Animals
Langue:
En
Journal:
Int J Biochem Cell Biol
Sujet du journal:
BIOQUIMICA
Année:
2020
Type de document:
Article
Pays d'affiliation:
Belgique