Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment.
Mar Pollut Bull
; 157: 111375, 2020 Aug.
Article
de En
| MEDLINE
| ID: mdl-32658716
ABSTRACT
At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g-1, 9 ng.g-1, and 18 ng.g-1) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antiviraux
/
Pneumopathie virale
/
Ivermectine
/
Infections à coronavirus
/
Pandémies
/
Nematoda
Limites:
Animals
/
Humans
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Mar Pollut Bull
Année:
2020
Type de document:
Article
Pays d'affiliation:
Tunisie