Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP.
Eur J Pharm Biopharm
; 154: 222-227, 2020 Sep.
Article
de En
| MEDLINE
| ID: mdl-32681967
ABSTRACT
A new method for determining solubility lines of drugs in polymers, based on low-frequency Raman spectroscopy measurements, is described and the results obtained by this method are compared with those obtained using a more classical method based on differential scanning calorimetry investigations. This method was applied to the paracetamol/PVP system using molecular and crystalline dispersions (MCD) rather than usual physical mixtures to reach faster the equilibrium saturated states and make the determination of the solubility line more rapid.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polyvinyles
/
Pyrrolidines
/
Analyse spectrale Raman
/
Acétaminophène
Langue:
En
Journal:
Eur J Pharm Biopharm
Sujet du journal:
FARMACIA
/
FARMACOLOGIA
Année:
2020
Type de document:
Article
Pays d'affiliation:
France