Practical approaches for diagnosis and management of prurigo nodularis: United States expert panel consensus.
J Am Acad Dermatol
; 84(3): 747-760, 2021 Mar.
Article
de En
| MEDLINE
| ID: mdl-32682025
ABSTRACT
BACKGROUND:
Prurigo nodularis (PN) is a chronic disease characterized by intensely pruritic, raised, nodular lesions. Because there are currently no United States Food and Drug Administration-approved therapies specifically for PN, management is highly variable, and no consensus exists on treatment regimens.OBJECTIVE:
To provide practical guidance to help United States dermatologists diagnose and effectively treat patients with PN.METHODS:
We participated in a roundtable discussion to develop consensus recommendations on diagnosis and treatment of PN from a United States perspective.RESULTS:
The core findings in PN are the presence of firm, nodular lesions; pruritus lasting at least 6 weeks; and a history or signs, or both, of repeated scratching, picking, or rubbing. The diagnostic workup involves a complete review of systems, considering potential systemic diseases, and assessment of disease severity, including disease burden and pruritus intensity. Treatment should be selected based on a patient's clinical presentation, comorbidities, and response to prior treatments and should address both neural and immunologic components of pruritus.LIMITATIONS:
Data on PN are from anecdotal or small clinical trials, and all treatments are currently used off-label.CONCLUSION:
An effective treatment approach for patients with PN should be based on clinical judgment and tailored to the individual needs of the patient.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Prurigo
/
Guides de bonnes pratiques cliniques comme sujet
/
Consensus
/
Produits dermatologiques
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Guideline
Limites:
Humans
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
J Am Acad Dermatol
Année:
2021
Type de document:
Article