Sterol synthesis pathway inhibition as a target for cancer treatment.
Cancer Lett
; 493: 19-30, 2020 11 28.
Article
de En
| MEDLINE
| ID: mdl-32711099
ABSTRACT
Sterol synthesis is a highly complex and integrated pathway in mammals. In the present review, we briefly summarize the main steps of this pathway, especially concerning its main rate-limiting enzymes, HMG-CoA reductase (HMGCR) and squalene epoxidase (SQLE), in relation with cancer. We focus on studies reporting key findings linking cholesterol with cancer. The inhibition of HMGCR and SQLE to prevent and inhibit cancer are reviewed. Finally, a pan-cancer review of publicly available data on genomic aberrations in the main enzymes involved in sterol biosynthesis and their transcription factors is reported, providing hitherto unexplored findings that may be the subject of future research in cancer metabolomics and tumor targeted treatment.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cholestérol
/
Voies de biosynthèse
/
Tumeurs
/
Antinéoplasiques
Limites:
Humans
Langue:
En
Journal:
Cancer Lett
Année:
2020
Type de document:
Article
Pays d'affiliation:
Italie