PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes.

White, Angela R; Tiwari, Durgesh; MacLeod, Molly C; Danzer, Steve C; Gross, Christina

White, Angela R; Tiwari, Durgesh; MacLeod, Molly C; Danzer, Steve C; Gross, Christina.

Affiliation

White AR; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Tiwari D; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA.
MacLeod MC; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Danzer SC; Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, OH 45229, USA.
Gross C; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA. Electronic address: christina.gross@cchmc.org.

Neurobiol Dis ; 144: 105026, 2020 10.

Article de En | MEDLINE | ID: mdl-32712265

Sujet(s)
Mots clés

Epilepsy; Mouse model; Neurodevelopmental disorder; PI3K; PTEN deficiency; Protein synthesis; Seizure; Signal transduction; p110ß

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Épilepsie / Phosphatidylinositol 3-kinases de classe I / Inhibiteurs des phosphoinositide-3 kinases / Neurones Type d'étude: Risk_factors_studies Limites: Animals Langue: En Journal: Neurobiol Dis Sujet du journal: NEUROLOGIA Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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