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Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.
Jiang, Bin; Duan, James J-W; Stachura, Sylwia; Karmakar, Ananta; Hemagiri, Hemalatha; Raut, Dhanya Kumar; Gupta, Arun Kumar; Weigelt, Carolyn A; Khan, Javed; Sack, John S; Wu, Dauh-Rurng; Yarde, Melissa; Shen, Ding-Ren; Galella, Michael A; Mathur, Arvind; Zhao, Qihong; Salter-Cid, Luisa M; Carter, Percy H; Dhar, T G Murali.
Affiliation
  • Jiang B; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States. Electronic address: bin.jiang@bms.com.
  • Duan JJ; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States. Electronic address: james.duan@bms.com.
  • Stachura S; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Karmakar A; Bristol Myers Squibb-Biocon Research Center, Bangalore, India.
  • Hemagiri H; Bristol Myers Squibb-Biocon Research Center, Bangalore, India.
  • Raut DK; Bristol Myers Squibb-Biocon Research Center, Bangalore, India.
  • Gupta AK; Bristol Myers Squibb-Biocon Research Center, Bangalore, India.
  • Weigelt CA; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Khan J; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Sack JS; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Wu DR; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Yarde M; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Shen DR; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Galella MA; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Mathur A; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Zhao Q; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Salter-Cid LM; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Carter PH; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Dhar TGM; Research and Early Development, Bristol Myers Squibb Company, Princeton, NJ 08543-4000, United States.
Bioorg Med Chem Lett ; 30(17): 127392, 2020 09 01.
Article de En | MEDLINE | ID: mdl-32738966
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrrolidines / Conception de médicament / Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2020 Type de document: Article Pays de publication: Royaume-Uni
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrrolidines / Conception de médicament / Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2020 Type de document: Article Pays de publication: Royaume-Uni