Correlating Ex Vivo Carotid Calcification Measurements With Cerebrovascular Symptoms: A Proof-of-Concept Study.
Stroke
; 51(9): e250-e253, 2020 09.
Article
de En
| MEDLINE
| ID: mdl-32755345
ABSTRACT
BACKGROUND AND PURPOSE:
The purpose of this study is to examine the ability of ex vivo derived Agatston, Volume, and Density-Volume calcium scores or calcium density measurements to differentiate between carotid plaques based on preoperative cerebrovascular symptomatology.METHODS:
Thirty-eight carotid plaques were acquired from standard endarterectomy. Micro-computed tomography was performed on the ex vivo samples. Image series were downsampled to represent the resolution of clinical multidetector computed tomography. Agatston, Volume, and Density-Volume carotid calcium scores were then calculated using coronary methodologies. The fractions of low- and high-density calcification were also determined.RESULTS:
The coronary calcium scores could not differentiate between carotid plaques from asymptomatic versus symptomatic patients. However, plaques from asymptomatic patients contained significantly lower fractions of low-density calcification and higher fractions of high-density calcification.CONCLUSIONS:
Screening for carotid calcium density in noncontrast computed tomography could reflect plaque stability.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Calcinose
/
Artériopathies carotidiennes
/
Angiopathies intracrâniennes
Type d'étude:
Diagnostic_studies
/
Etiology_studies
Limites:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Stroke
Année:
2020
Type de document:
Article
Pays d'affiliation:
Irlande