A Case of Paraneoplastic Myoclonus Attributed to Non-Small Cell Lung Cancer.
Tremor Other Hyperkinet Mov (N Y)
; 10: 7, 2020 06 16.
Article
de En
| MEDLINE
| ID: mdl-32775021
ABSTRACT
Background:
It is well known that myoclonus can be a paraneoplastic manifestation of underlying malignancy. Case Report A 78-year-old male diagnosed with papillary variant non-small cell lung cancer (NSCLC) presented with tremulousness that rapidly evolved into severe, diffuse myoclonus with prominent palatal involvement requiring intubation. The generalized myoclonus resolved with on levetiracetam, chemotherapy and immune modulation. While low titer positive P/Q type calcium channel autoantibodies were detected, it's etiologic relevance is unclear.Discussion:
This case highlights a rare neurologic paraneoplastic presentation of papillary NSCLC. It also illustrates the importance of monitoring airway safety when myoclonus is generalized. Highlights A new, rare paraneoplastic presentation of papillary variant non-small cell lung adenocarcinoma is described. The patient presented with severe diffuse myoclonus with prominent palatal involvement without encephalitis that responded to a combination of chemotherapy, immune modulation, and levetiracetam. No clear causal antibody was found.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Adénocarcinome papillaire
/
Protocoles de polychimiothérapie antinéoplasique
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Carcinome pulmonaire non à petites cellules
/
Syndromes neurologiques paranéoplasiques
/
Tumeurs du poumon
/
Myoclonie
Type d'étude:
Diagnostic_studies
/
Etiology_studies
Limites:
Aged
/
Humans
/
Male
Langue:
En
Journal:
Tremor Other Hyperkinet Mov (N Y)
Année:
2020
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique