Lassa Fever Induced Hearing Loss: The Neglected Disability of Hemorrhagic Fever.
Int J Infect Dis
; 100: 82-87, 2020 Nov.
Article
de En
| MEDLINE
| ID: mdl-32795603
ABSTRACT
OBJECTIVE:
Lassa fever (LF) a hemorrhagic fever endemic to Western has an incidence of approximately 500,000 cases per year. Here, we evaluate hearing loss and other sequelae following LF.METHODS:
This case-control study enrolled laboratory confirmed LF survivors, non-LF Febrile controls and Matched Community controls with no history of LF or recent hospitalization for a febrile illness. Study participants completed a symptom questionnaire. Pure-tone audiometry was completed by a subset of participants.RESULTS:
One hundred forty-seven subjects were enrolled aged from 3-66 years (mean = 23.3). LF survivors were significantly more likely to report balance difficulties (55% vs 20%, p < 0.001), hair loss (32% vs 7%, p < 0.001), difficulty speaking (19% vs 1%, p < 0.001), social isolation (50% vs 0%, p < 0.001), and hearing loss (17% vs 1%, p = 0.002) in comparison to Matched-Community Controls. Similar trends were noted in comparison to Febrile Controls, although these findings were non-significant. Fifty subjects completed audiometry. Audiometry found that LF survivors had significantly more bilateral hearing loss in comparison to Matched-Community Controls (30% vs 4%, p = 0.029).CONCLUSION:
This study characterizes the sequelae of LF and highlights the need for increased access to hearing care in West Africa.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Perte d'audition
/
Fièvre de Lassa
Type d'étude:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Africa
Langue:
En
Journal:
Int J Infect Dis
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2020
Type de document:
Article