Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.

Kimhofer, Torben; Lodge, Samantha; Whiley, Luke; Gray, Nicola; Loo, Ruey Leng; Lawler, Nathan G; Nitschke, Philipp; Bong, Sze-How; Morrison, David L; Begum, Sofina; Richards, Toby; Yeap, Bu B; Smith, Chris; Smith, Kenneth G C; Holmes, Elaine; Nicholson, Jeremy K

Kimhofer, Torben; Lodge, Samantha; Whiley, Luke; Gray, Nicola; Loo, Ruey Leng; Lawler, Nathan G; Nitschke, Philipp; Bong, Sze-How; Morrison, David L; Begum, Sofina; Richards, Toby; Yeap, Bu B; Smith, Chris; Smith, Kenneth G C; Holmes, Elaine; Nicholson, Jeremy K.

Affiliation

Kimhofer T; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Lodge S; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Whiley L; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Gray N; Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.
Loo RL; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Lawler NG; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Nitschke P; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Bong SH; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Morrison DL; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Begum S; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Richards T; Section for Nutrition Research, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K.
Yeap BB; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia.
Smith C; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia.
Smith KGC; The Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, U.K.
Holmes E; The Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, U.K.
Nicholson JK; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

J Proteome Res ; 19(11): 4442-4454, 2020 11 06.

Article de En | MEDLINE | ID: mdl-32806897

Sujet(s)
Mots clés

COVID-19; NMR spectroscopy; SARS-CoV-2; amino acids; biomarkers; lipoproteins; mass spectrometry; metabolic phenotyping; mosaic disease; multiorgan damage; systems model

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pneumopathie virale / Infections à coronavirus / Pandémies / Acides aminés / Lipoprotéines / Modèles biologiques / Défaillance multiviscérale Type d'étude: Etiology_studies / Prognostic_studies Limites: Aged / Female / Humans / Male / Middle aged Langue: En Journal: J Proteome Res Sujet du journal: BIOQUIMICA Année: 2020 Type de document: Article Pays d'affiliation: Australie Pays de publication: États-Unis d'Amérique

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