4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates.

Hirata, Katsuya; Nambara, Toshihiko; Kawatani, Keiji; Nawa, Nobutoshi; Yoshimatsu, Hidetaka; Kusakabe, Haruna; Banno, Kimihiko; Nishimura, Ken; Ohtaka, Manami; Nakanishi, Mahito; Taniguchi, Hidetoshi; Arahori, Hitomi; Wada, Kazuko; Ozono, Keiichi; Kitabatake, Yasuji

Hirata, Katsuya; Nambara, Toshihiko; Kawatani, Keiji; Nawa, Nobutoshi; Yoshimatsu, Hidetaka; Kusakabe, Haruna; Banno, Kimihiko; Nishimura, Ken; Ohtaka, Manami; Nakanishi, Mahito; Taniguchi, Hidetoshi; Arahori, Hitomi; Wada, Kazuko; Ozono, Keiichi; Kitabatake, Yasuji.

Affiliation

Hirata K; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Nambara T; Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, 594-1101, Japan.
Kawatani K; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Nawa N; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Yoshimatsu H; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Kusakabe H; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Banno K; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Nishimura K; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Ohtaka M; Department of Physiology II, Nara Medical University, Kashihara, Nara, 634-8521, Japan.
Nakanishi M; Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Taniguchi H; Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8562, Japan.
Arahori H; TOKIWA-Bio, Inc, Tsukuba Center Inc. (TCI), Tsukuba, Ibaraki, 305-0047, Japan.
Wada K; Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8562, Japan.
Ozono K; TOKIWA-Bio, Inc, Tsukuba Center Inc. (TCI), Tsukuba, Ibaraki, 305-0047, Japan.
Kitabatake Y; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.

Sci Rep ; 10(1): 14047, 2020 08 20.

Article de En | MEDLINE | ID: mdl-32820178

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénylbutyrates / Apoptose / Syndrome de Down / Agrégats de protéines / Neurones Limites: Humans Langue: En Journal: Sci Rep Année: 2020 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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